Authors: Aneta Pop, Emilia Balint, N. Manolescu, I. Stefanescu, Manuela Militaru
Roumanian Biotechnological Letters; Vol. 13, No. 6, supplement, 2008, pp. 74-77

Abstract

The aim of the current research was to investigate the deuterium depleted water (DDW) effect on animals treated with anticancer drugs Vinblastine, Cyclophosphamide, 5-Fluorouracil and Farmarubicine.

There were used two groups of 10 rats for each cytostatic, one group received 60 ppm DDW as daily diet before, during and after chemotherapy and the second group received tap water in the same conditions. Other two groups housed in the same conditions received DDW and tap water without any medication.

There were recorded differences in the amount of serum glycoproteins and also the glycosylation degree and pattern. DDW administration induced a significant decrease of serum total glycoproteins and of glycosylation degree in all animals, both cytostatics treated or not.

Fucose Raphanus sativus lectin interaction revealed that DDW induced also changes in the glycosylated domain, because it interacted only with the sera from 5-Fluorouracil treated rats that had not received DDW.