Authors: Lucia Olariu, Mihaela Petcu, Camelia Tulcan, Iuliana Chis-Buiga, Mihaela Pup,M.Florin, Ileana Brudiu.
Published in: Lucrari Stiintifice Medicina Veterinara Vol. XL, 2007, Timisoara

Abstract

In the present work we studied the changes in some red blood cell antioxidant enzymes which are involved in the organism’s antioxidant system after administration of deuterium depleted water (DDW) in rats, during a 60 days experimental period.

There was determined that in a short time treatment, DDW had a prooxidant effect (malondialdehide values are increasing) but after a loger time administration, DDW stimulated the cell antioxidant defense system. GSHred (p< 0.001), respectively SOD registered increased values (p< 0.05). This conclusions were revealed by the determination of glutathione average values,glutathione peroxidase, glutathione reductase, catalase and superoxide dismutase activities. A role for oxidative stress was postulated in many conditions: aging, inflammatory conditions, atherosclerosis, etc. In many cases, that follows after increased amounts of free radical damage products in body fluids. Lipid peroxidation is an inevitable accompaniment of cell death from any causes. Evidence of oxidative stress installation should be detectable before the onset of tissue damage and increasing of antioxidant status at an early stage should either prevent or greatly reduce tissue damages (2,3,9). In this content many researchers studied the benefic effects of many natural antioxidants. Since 1992, a great importance was revealed to deuterium content in water. It has been known for decades that due to the mass differences between hydrogen and deuterium, molecules with deuterium content behave differently in chemical reactions which are evident in the biological system as well.